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Coronary artery vasospasm including Prinzmetal's angina see Warnings and Precautions (5.1). Drug Interactions See also Drug Interactions (7). The adverse reaction profile seen with Maxalt-MLT Orally Disintegrating Tablets was similar to that seen with Maxalt Tablets. Following oral administration of 14C-rizatriptan, rizatriptan accounted for about 17 of circulating plasma radioactivity. The AUC of the active N-monodesmethyl metabolite of rizatriptan was not affected by propranolol see dosage AND administration and drug interactions. Maxalt should not be administered to patients with a history of stroke or transient ischemic attack see contraindications. The most common samples adverse reactions during treatment with Maxalt (5 in either treatment group and greater than placebo) were asthenia/fatigue, somnolence, pain/pressure sensation and dizziness. 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In patients who experience symptoms or signs suggestive maxalt of non-coronary vasospasm reaction following the use of any 5-HT1 agonist, the suspected vasospasm reaction should be ruled out before receiving additional maxalt doses. Talk to your doctor about the best way to feed your baby if you take maxalt. If you become pregnant while taking maxalt, talk to your healthcare provider about registering with the pregnancy registry at the Merck National Service Center. General Information about the safe and effective use of maxalt. Maxalt may cause serious side effects. Propranolol : In a study of concurrent administration of propranolol 240 mg/day and a single dose of rizatriptan 10 mg in healthy adult subjects (n11 mean plasma AUC for rizatriptan was increased by 70 during propranolol administration, and a four-fold. Patient Counseling Information See FDA-Approved Patient Labeling ( patient information ). 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If your migraine is not eased after taking the first dose, a further dose is unlikely to work, so do not take a second tablet/wafer. This is because the food in your stomach can delay the absorption of the medicine. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and maxalt within 24 hours is contraindicated see contraindications. Indications, indications, maxalt and maxalt-MLT are indicated for the acute treatment of migraine with or without aura samples in adults and in pediatric patients 6 to 17 years old.

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